Therapeutic drug monitoring (eculizumab · ravulizumab · crovalimab)

Model-informed precision dosing of therapeutic monoclonal antibodies for complement-mediated diseases. Privacy note: this app runs locally on your computer after downloading the webpage. No data are stored or processed online. All calculations are performed locally on the device you are using this website on.
1 Drug & weight 2 Add doses & samples 3 Run forecast 4 Explore regimen (optional)

1 Drug & patient

Trough target – change

2 Dosing schedule & measured concentrations

Was the patient treated with this drug before the first dose entered above?
If earlier doses are missing, enter them (then answer No), or use Steady state mode if the patient has been on the same regimen for months.
Planned regimen after the last entered dose (optional)
Leave both empty to continue with the interval and dose found in the entered history.

Measured concentrations

Assay settings (LLOQ, error multiplier)
Default 1. Leave unchanged unless your lab advises otherwise.

3 Forecast

Inputs changed. Press “Run forecast” to update.
Advanced fitting options
How to read these results
  • Band (5–95%): 90% plausible range for the true concentration. It does not include assay error, so a future measured value may fall outside it.
  • P(trough > target): chance the true trough stays above your target, at your chosen dates.
  • Median trough [5–95%]: the same distribution in µg/mL.

4 Regimen explorer

Run a forecast in card 3 first. This explorer reuses that fit's own parameters.